Recently, the team with Professor Wang Mang from Faculty of Chemistry, NENU as leader made new progress in Trifluoromethylation methodology field. This study prepared N-CF3 Azoles with multiple structures for the first time based on cyclic reaction between N-CF3 Nitrile Onium Ions and 1,3-Dipoles. The result was published on Angewandte Chemie International Edition, an international famous journal (impact factor: 15.336). Professor Wang Mang, from Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, NENU, Xu Cong, a young teacher, and Professor Guan Wei, Functional Materials Chemistry Research Laboratory, Faculty of Chemistry, NENU are corresponding authors of the thesis, and Zhang Ruzhong, a doctoral student, is first author of it.
In recent days, they used PhICF3Cl again as an effective Trifluoromethyl source, and made important progress in new synthetic strategy research of N-Trifluoromethyl Azole compound.
This work was funded by National Natural Science Foundation of China (21672032 and 21802016), Science and Technology Department of Jilin Province (20190103127JH and 20200201067JC), and The Education Department of Jilin Province (JJKH20201166KJ).
(From Faculty of Chemistry, NENU, translated by Zhang Zenghua, revised by Chen Yanxu)
