Recently, Professor Wang Mang and Associate Professor Xu Cong's team from the School of Chemistry made a significant breakthrough in the field of trifluoromethylation methodology research. The team focused on the challenging issues in the field of trifluoromethylation methodology, specifically tackling the scientific problem of the difficulty in directly trifluoromethylating relatively hard heteroatom nucleophiles.
Their research successfully addressed the aforementioned challenges in two areas of fluorine chemistry. Through the ligand exchange between CPTFI and carboxylate ions, they obtained acyloxy (phenyl) trifluoromethyl iodide (APTFI) and achieved carboxylic acid O-trifluoromethylation under the activation of zinc chloride.
The corresponding authors of this achievement are Associate Professor Xu Cong and Professor Wang Mang from the School of Chemistry, with doctoral students Zhu Hongye and Gao Chi as the first authors. This work was supported by grants from the National Natural Science Foundation and the Natural Science Foundation of Jilin Province, among others.
(From News Center, translated by Zhu Yanan, revised by Chen Yanxu)
